From the A1 highway, exit at Orte and follow road signs to the town center (about 4,5 km away from the exit).
Orvieto is approximately one hour away from Rome by car and one hour and 45 minutes away from Florence. It is one hour away from Terni and Perugia and less than an hour from Viterbo.
Another main solution is the E45 if you come from Perugia: exit at “Orvieto-Todi”, take the SS71, and follow road signs to Orvieto.
The main Umbria towns (perugia, Assisi, Gubbio, Spoleto, Terni) can be reached via the E45. You can also get to Orvieto via the SS2 (Cassia) that goes down from Buonviaggio-Villanova with a scenic route and a parking area called “Il Belvedere di Orvieto”.